FAQ
- Can I set up MatchMiner at my institution?
- Yes, MatchMiner is open source and you can set it up at your institution. Matchminer is HIPAA compliant when hosted behind an institutional firewall. Additional information, including instructions to set up a demo instance, are available in our Gitbook.
- What are the data requirements to set up MatchMiner at my institution?
- What are the software requirements to set up MatchMiner at my institution?
- A small instance of MatchMiner can be run locally on a laptop using 4 CPUs and 4GB of memory. A larger instance (e.g. similar to what is currently run at Dana-Farber Cancer Institute [DFCI]) with ~60,000 clinical samples, ~400 trials, ~600 filters, and ~500 users would use 45 CPU cores and 128 GB of memory.
- What are the personnel requirements to set up MatchMiner at my institution?
- For trial curation, at least 2 scientists are suggested for curating and reviewing CTML documents. For software implementation, at least 1 software engineer is required to set up MatchMiner, including development of data ingestion pipelines and integration with institutional systems (e.g. authentication) as needed.
- Where can I find documentation on MatchMiner?
- Where can I find the open source code for MatchMiner (MatchEngine, GUI)?
- How can trial eligibility be curated into CTML?
- Who are the main users of MatchMiner?
- Clinicians, clinical research staff, and trial investigators can use MatchMiner to identify trial matches.
- What is the clinical impact of MatchMiner at DFCI?
- In January 2022, with ~170 open precision medicine trials at Dana-Farber Cancer Institute (DFCI), patients matched to 6 trials on average and 84% of patients had at least one trial match. As of January 2022, 220+ patients have enrolled onto clinical trials as a result of MatchMiner.
- Can DFCI clinical trial CTMLs be shared with my institution/company?
- No, CTMLs are not available for sharing at this time.
- Can DFCI patient data be shared with my institution/company?
- Deidentified genomic data and limited clinical data can be accessed through AACR Project GENIE. No other patient data is available for sharing at this time.
- I have a question that isn’t answered here, how can I contact the MatchMiner team at DFCI?
- What should I do if I encounter any bugs or server issues?